Chicago, IL (SportsNetwork.com) - Josh Harrison stroked a two-run homer and drove in three to help lead the Pittsburgh Pirates to a 5-3 win against the Chicago Cubs in the middle contest of a three-game set at Wrigley Field on Saturday.

Jordy Mercer connected on a solo shot and scored two runs while Andrew McCutchen collected an RBI for the Pirates, who lost four of their last five coming in.

In his second start of the season, Vance Worley (1-0) tossed an effective 6 2/3 innings, allowing three runs on five hits with four strikeouts to pick up his first win in over a year.

Travis Wood (7-6) surrendered three runs on four hits and three walks while fanning four in just 4 2/3 innings to absorb the loss.

Anthony Rizzo crushed a two-run home run for the Cubs, who had a two-game winning streak snapped.

Mercer smacked a leadoff solo shot to left in the third to put the Pirates on the board first.

Chris Coghlan's base hit to start the fourth was the Cubs first hit of the game. The second hit came two batters later when Rizzo smashed a two-run homer deep over the ivy in right to put the Cubs ahead 2-1.

Harrison's two-out single to center in the fifth plated Mercer, who started the inning with a base hit. McCutchen followed with an RBI single to left that scored Gregory Polanco, who was walked to reach base, to make it 3-2.

An overturned challenge on a Polanco two-out, infield single kept the seventh inning alive and Harrison followed with a home run to right to increase the cushion to 5-2.

The Cubs got a run back in the home half on a Eli Whiteside double to center. Junior Lake singled and was moved to second on a force out.

Mark Melancon struck out the side in the ninth to earn his 11th save of the season.