Boston, MA (Sports Network) - Mark Buehrle tossed six effective innings and handed Clay Buchholz his first loss of the season, as Toronto bested Boston, 4-2, in the middle test of a three-game series from Fenway Park.

Buehrle (12-9) scattered five hits and one run while fanning five, and three Toronto relievers held their hosts hitless over the final three frames. Casey Janssen was the last of the bunch, recording his 33rd save with a spotless ninth.

Adam Lind, Rajai Davis and J.P. Arencibia drove in a run each for the Blue Jays, who recovered from a 6-3 loss in Friday's opener.

Buchholz (11-1), tasked with taking the hill less than 24 hours after his club clinched the AL East title, also worked six innings but allowed three runs on six hits. The right-hander experienced his first defeat since Oct. 1, 2012 against the Yankees, then last of five straight setbacks to end the year.

Jonny Gomes and David Ross knocked in runs for the Red Sox, who have dropped three of their last five.

The Jays broke through for three runs in the fourth. Brett Lawrie kept the frame alive with a two-out single, then scored when Lind followed with a double. Moises Sierra's single put runners on the corners, then Davis singled in another run and Sierra scored on a Buchholz throwing error.

Boston finally answered in the sixth as Gomes singled home Stephen Drew with one down, but Daniel Nava grounded into an inning-ending double play with runners on the corners.

It was 3-2 in the home seventh, as Xander Bogaerts reached second on Lawrie's error, moved up on a wild pitch and scored on a Ross groundout.

Toronto picked up an insurance run in the top of the ninth, as Davis worked a leadoff walk, was sacrificed to second and came around on an Arencibia base hit.

Dustin McGowan, Sergio Santos and Janssen combined to send down the final seven Red Sox batters to finish off the win.